The majority of the exciting stuff needs a number of tweaks to function. Outside of the list, I'll link to them here. The majority of the other items on this list won't function without them, so be sure you have them installed. The vast majority of the mods I use come from NexusMods, which also frequently links to mods that are not hosted on its own website. 

How to have the best Fallout New Vegas experience in 2022

Unquestionably, you require a mod manager application. I suggest the Fallout Mod Organizer (FMO) or the Fallout Mod Manager (FOMM) (FOMO). Both may be connected to Nexus and will let you automatically install the majority of mods. Making a modded game function properly also requires the usage of the Load Order Optimization Tool (LOOT).

Gameplay Requirements: How to have the best Fallout New Vegas experience in 2022

New Vegas Anti Crash - NVAC; New Vegas Enhanced Content - NVEC; JohnnyGuitar NVSE; NV Compatibility Skeleton; Essential Visual Enhancements - EVE; 4GB Fallout New Vegas Updated; Unofficial Patch NVSE Plus; The Mod Configuration Menu; Yukichigai Unofficial Patch - YUP; Functional Post Game Ending - FPGE; New Vegas Script Extender - NVSE.

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Install these mods to have the best fallout new vegas experience in 2022:

A Tale of Two Wastelands (TTW)

I recently installed this one and so far I'm really enjoying it even though it's new to me. You can combine Fallout 3 and all of its DLC into Fallout: New Vegas with the help of A Tale of Two Wastelands, allowing you to complete both games in one sitting. The New Vegas system has been upgraded to work with Fallout 3. This mod isn't just FO3 in New Vegas because of the removed and added content, solved bugs, and other changes. It is a distinct game that differs from the original material.

Beyond Boulder Dome

I prefer large quest mods that add a tonne of new content and new world locations. Beyond Boulder Dome is the best location for this. I also like to travel to new places in the country, and Boulder, Colorado is a great addition.

Prior to the conflict, the Boulder Dome was built as a model for future communities off the planet. It was a centre for science and education that could survive a nuclear war. But it did survive.

Masters of the Madre

When you're feeling a little more homicidal than usual, the Masters of the Madre mod is perfect. There is a strong relationship between this and the Dead Money DLC for New Vegas. In an alternative conclusion, the player can cooperate with Elijah to use holograms and the Cloud to eliminate the NCR and seize control of the Mojave. Usually, the player is forced to load an older save and choose the conventional ending after watching the cut scene that jumps to years later.